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Contos chapados

An Essential Role for Liver ERα in PubMed Central (PMC)

The Selective Ablation of Esr1 Leads to an Aberrant Deposition of Fat and Collagen in the Female Mouse Liver. The effects of liver Esr1 ablation were initially studied in fertile females euthanized at 10 months of age. The livers of syngenic (SYN) and LERKO mice were dissected for morphological examination based on a combination of staining procedures (Figure 1 A; Table S1).

Effects of high fructose intake on liver injury

1. Introduction. Nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide and becoming the most frequent disease of the liver. Nonalcoholic steatohepatitis (NASH) is a severe form of NAFLD characterized with sustained inflammation and fibrosis, eventually developing into liver cirrhosis and hepatocellular carcinoma (Sugimoto and Takei, 2011).

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04.edgar allan poe ficção completa contos de terror, mistério e morte o rei peste 1. EDGAR ALLAN POE – FICÇÃO COMPLETA CONTOS DE TERROR, MISTÉRIO E MORTE O REI PESTE CONTO ALEGÓRICO Os deuses suportam nos reis, e permitem, as coisas que odeiam em meio à rale.

An Essential Role for Liver ERα in Coupling Hepatic

Della Torre et al. show that ERα activity in the mouse female liver is essential for balanced lipid and cholesterol metabolism. Lack of liver ERα activation in the case of ovarian failure leads to metabolic dysfunction that may be linked to post menopausal disease.

An Essential Role for Liver ERα in Coupling Hepatic

Interestingly, when the study was carried out in 10 month old SYN males, we observed that the lipid accumulation was 4.4 fold higher than in females of the same age; however, the effect of Esr1 ablation in males ( 28%) was less pronounced than in females ( 112%; Figure S1), thus suggesting a sexually dimorphic role of hepatic ERα in the control of liver lipid homeostasis.